A new cytotoxic friedelane acid--pluricostatic acid--and other compounds from the leaves of Marila pluricostata.

نویسندگان

  • Dionisio A Olmedo
  • José L López-Pérez
  • Esther del Olmo
  • Yelkaira Vásquez
  • Arturo San Feliciano
  • Mahabir P Gupta
چکیده

Bioassay-guided fractionation of the dichloromethane extract of the leaves of Marila pluricostata led to the isolation of 2alpha,3beta-dihydroxy-D:A-friedoolean-28-oic acid (pluricostatic acid), a new friedelane triterpenoid, (1), ten known triterpenoids and three sterols. Their chemical structures were elucidated through spectroscopic analysis. The less polar fractions, on GC/MS analysis and comparison with a MS library, resulted in the identification of twenty four sesquiterpenoids. The new triterpenoid acid 1 showed cytotoxicity against the MCF-7, H-460, and SF-268 human cancer cell lines with GI(50) values from 1.2 to 3.3 microg/mL.

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عنوان ژورنال:
  • Molecules

دوره 13 11  شماره 

صفحات  -

تاریخ انتشار 2008